JPET #214932 PiP

JPET #53298 PiP

JPET #103465 PiP 1 Title: Role of Matrix Metalloproteinases in Intestinal Inflammation Authors:

JPET #166769 PiP 1 Mechanisms of Cadmium-Induced Proximal Tubule Injury: New Insights with Implications for Biomonitoring and Therapeutic Interventions

JPET #173948 PIP Perspectives in Pharmacology Functional Selectivity and Biased Receptor Signaling

With the emergence of information describing functional selectivity and biased agonists and antagonists has come a lack of confidence in ‘one size fits all’ assays for detection of agonism. Seven transmembrane receptors (7TMRs) are pleiotropic with respect to the signaling protein to which they couple in a cell and many conformations of the receptor can be formed; this leads to systems where li...

Jpet #166710 Pip Behavioral Indices in Antipsychotic Drug Discovery

Schizophrenia is characterized by three major symptom classes: positive symptoms, negative symptoms and cognitive deficits. Classical antipsychotics (phenothiazines, thioxanthines, butyophenones) are effective against positive symptoms but induce major side-effects, in particular extrapyramidal symptoms (EPS). The discovery of clozapine, which does not induce EPS and is thought effective agains...